Vicissitude

vɨˈsɪs.ɨˌt(j)u(ː)d], [vaɪˈsɪs.ɨˌt(j)u(ː)d]

Noun

vicissitude (plural vicissitudes)

1. Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.Synonyms: ups and downs
   1. (often, in the plural) A change, especially in one’s life or fortunes